Down-regulation of nuclear HMGB1 reduces ischemia-induced HMGB1 translocation and release and protects against liver ischemia-reperfusion injury

Hepatocyte-specific HMGB1 deletion has been found to worsen the injury and inflammation in liver ischemia-reperfusion injury (IRI), highlighting a role for intracellular HMGB1 in cellular protection. Down-regulation of nuclear HMGB1 by small interfering RNA (siRNA) might not only decrease its injuri...

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Publicado no:Sci Rep
Main Authors: Zhao, Guangyuan, Fu, Cheng, Wang, Lu, Zhu, Lan, Yan, Yutao, Xiang, Ying, Zheng, Fang, Gong, Feili, Chen, Song, Chen, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382773/
https://ncbi.nlm.nih.gov/pubmed/28382970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46272
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