Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages

Activation of TLR4 by lipopolysaccharide (LPS) induces both pro-inflammatory and anti-inflammatory cytokine production in macrophages. Type 4 phosphodiesterases (PDE4) are key cAMP-hydrolyzing enzymes, and PDE4 inhibitors are considered as immunosuppressors to various inflammatory responses. We demo...

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Vydáno v:Sci Rep
Hlavní autoři: Yang, Jing-Xing, Hsieh, Kou-Chou, Chen, Yi-Ling, Lee, Chien-Kuo, Conti, Marco, Chuang, Tsung-Hsien, Wu, Chin-Pyng, Jin, S.-L. Catherine
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382768/
https://ncbi.nlm.nih.gov/pubmed/28383060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46165
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