The intratracheal administration of endotoxin and cytokines. III. The interleukin-1 (IL-1) receptor antagonist inhibits endotoxin- and IL-1-induced acute inflammation.

Endotoxin, a lipopolysaccharide (LPS) component of gram-negative bacteria, induces alveolar macrophages to express interleukin-1 (IL-1). Lipopolysaccharide and IL-1 both cause severe acute neutrophilic inflammation in the lung after intratracheal injection, suggesting that LPS-induced IL-1 expressio...

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Bibliographic Details
Main Authors: Ulich, T. R., Yin, S. M., Guo, K. Z., del Castillo, J., Eisenberg, S. P., Thompson, R. C.
Format: Artigo
Language:Inglês
Published: 1991
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1886271/
https://ncbi.nlm.nih.gov/pubmed/1825745
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