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Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model

BACKGROUND: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservation present in these protein sequences presumably are due to selective constraints maintaining important but unknown struc...

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Bibliographic Details
Main Authors: Neuwald, Andrew F, Liu, Jun S
Format: Artigo
Language:Inglês
Published: BioMed Central 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC538276/
https://ncbi.nlm.nih.gov/pubmed/15504234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-5-157
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