CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin

BACKGROUND: Granulosa cell tumors (GCTs) are relatively rare and are subtypes of the sex-cord stromal neoplasms. Methylation induced silencing in the promoters of genes such as tumor suppressor genes, DNA repair genes and pro-apoptotic genes is recognised as a critical factor in cancer development....

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Bibliographic Details
Main Authors: Dhillon, Varinderpal S, Shahid, Mohd, Husain, Syed Akhtar
Format: Artigo
Language:Inglês
Published: BioMed Central 2004
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC538268/
https://ncbi.nlm.nih.gov/pubmed/15574200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-3-33
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