Understanding CD8(+) T-cell responses toward the native and alternate HLA-A*02:01-restricted WT1 epitope

The Wilms' tumor 1 (WT1) antigen is expressed in solid and hematological malignancies, but not healthy tissues, making it a promising target for cancer immunotherapies. Immunodominant WT1 epitopes, the native HLA-A2/WT1(126-134) (RMFPNAPYL) (HLA-A2/RMFPNAPYL epitope (WT1A)) and its modified var...

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Enregistré dans:
Détails bibliographiques
Publié dans:Clin Transl Immunology
Auteurs principaux: Nguyen, Thi HO, Tan, Amabel CL, Xiang, Sue D, Goubier, Anne, Harland, Kim L, Clemens, E Bridie, Plebanski, Magdalena, Kedzierska, Katherine
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382434/
https://ncbi.nlm.nih.gov/pubmed/28435676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cti.2017.4
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