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Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I
Glyoxalase I plays a critical role in the enzymatic defence against glycation by catalysing the isomerization of hemithioacetal, formed spontaneously from cytotoxic α-oxoaldehydes and glutathione, to (S)-α-hydroxyacylglutathione derivatives. Upon the hydrolysis of the thioesters catalysed by glyoxal...
में बचाया:
में प्रकाशित: | Nat Commun |
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मुख्य लेखकों: | , , , |
स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
Nature Publishing Group
2017
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5382281/ https://ncbi.nlm.nih.gov/pubmed/28374736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14877 |
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