Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging

Cognitive decline is a major biomedical challenge as the global population ages. Elevated levels of the longevity factor klotho suppress aging, enhance cognition, and promote synaptic plasticity and neural resilience against aging and Alzheimer’s disease (AD)-related pathogenic proteins. Here, we ex...

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Detalhes bibliográficos
Publicado no:Brain Imaging Behav
Main Authors: Yokoyama, Jennifer S., Marx, Gabe, Brown, Jesse A., Bonham, Luke W., Wang, Dan, Coppola, Giovanni, Seeley, William W., Rosen, Howard J., Miller, Bruce L., Kramer, Joel H., Dubal, Dena B.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2016
Assuntos:
SI: Resilience/Reserve in AD
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382127/
https://ncbi.nlm.nih.gov/pubmed/27714549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11682-016-9598-2
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