Fludarabine with pharmacokinetically-guided IV busulfan is superior to fixed-dose delivery in pretransplant conditioning of AML/MDS patients

We hypothesized that IV Busulfan (Bu) dosing could be safely intensified through pharmacokinetic (PK-) dose guidance to minimize the inter-patient variability in systemic exposure (SE) associated with body-sized dosing, and this should improve outcome of AML/MDS patients undergoing allogeneic stem c...

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Detalhes bibliográficos
Publicado no:Bone Marrow Transplant
Main Authors: Andersson, Borje S., Thall, Peter F., Valdez, Benigno C., Milton, Denái R., Al-Atrash, Gheath, Chen, Julianne, Gulbis, Alison, Chu, Diem, Martinez, Charles, Parmar, Simrit, Popat, Uday, Nieto, Yago, Kebriaei, Partow, Alousi, Amin, de Lima, Marcos, Rondon, Gabriela, Meng, Qing H., Myers, Alan, Kawedia, Jitesh, Worth, Laura L., Fernandez-Vina, Marcelo, Madden, Timothy, Shpall, Elizabeth J., Jones, Roy B., Champlin, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382042/
https://ncbi.nlm.nih.gov/pubmed/27991894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bmt.2016.322
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