Diphtheria toxin and its ADP-ribosyltransferase-defective homologue CRM197 possess deoxyribonuclease activity.

The cytotoxic mechanism of diphtheria toxin (DTx) is associated with its ability to inhibit protein synthesis by ADP-ribosylation of elongation factor 2. Although DTx intoxication leads to internucleosomal DNA cleavage and cell lysis, these events do not occur when protein synthesis is inhibited by...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Bruce, C, Baldwin, R L, Lessnick, S L, Wisnieski, B J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53820/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2109323/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.8.2995
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