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Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening
Structure based drug discovery on GPCRs harness atomic detail X-ray binding pockets and large libraries of potential drug lead candidates in virtual screening (VS) to identify novel lead candidates. Relatively small conformational differences between such binding pockets can be critical to the succe...
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| Publié dans: | PLoS One |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5381884/ https://ncbi.nlm.nih.gov/pubmed/28380046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174719 |
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