RUNX1 induces DNA replication independent of active DNA demethylation at SPI1 regulatory regions

BACKGROUND: SPI1 is an essential transcription factor (TF) for the hematopoietic lineage, in which its expression is tightly controlled through a −17-kb upstream regulatory region and a promoter region. Both regulatory regions are demethylated during hematopoietic development, although how the chang...

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Veröffentlicht in:BMC Mol Biol
Hauptverfasser: Goyal, Shubham, Suzuki, Takahiro, Li, Jing-Ru, Maeda, Shiori, Kishima, Mami, Nishimura, Hajime, Shimizu, Yuri, Suzuki, Harukazu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381148/
https://ncbi.nlm.nih.gov/pubmed/28376714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12867-017-0087-y
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