A lignan induces lysosomal dependent degradation of FoxM1 protein to suppress β-catenin nuclear translocation

Colon cancer is one of the most common cancers. In this study, we isolated a lignan [(−)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol, DFS] from Alnus japonica (Betulaceae) and investigated its biological activity and mechanism of action on colon cancer. DFS reduced the viability of colon cancer cel...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dong, Guang-zhi, Jeong, Ji Hye, Lee, Yu-ih, Han, Yeong Eun, Shin, Jung Sook, Kim, Yoon-Jung, Jeon, Raok, Kim, Young Hwa, Park, Tae Jun, Kim, Keun Il, Ryu, Jae-Ha
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380986/
https://ncbi.nlm.nih.gov/pubmed/28378765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45951
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