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MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses

Activation of NF-κB transcription factor is strictly regulated to prevent excessive inflammatory responses leading to immunopathology. However, it still remains unclear how NF-κB activation is negatively controlled. The PDZ-LIM domain-containing protein PDLIM2 is a nuclear ubiquitin E3 ligase target...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Shin, Chanyoung, Ito, Yuma, Ichikawa, Shota, Tokunaga, Makio, Sakata-Sogawa, Kumiko, Tanaka, Takashi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380948/
https://ncbi.nlm.nih.gov/pubmed/28378844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46097
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