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PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm

Understanding the regulatory mechanisms for the NF-κB transcription factor is key to control inflammation. IκBα maintains NF-κB in an inactive form in the cytoplasm of unstimulated cells, whereas nuclear NF-κB in activated cells is degraded by PDLIM2, a nuclear ubiquitin E3 ligase that belongs to a...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Ono, Rumiko, Kaisho, Tsuneyasu, Tanaka, Takashi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683373/
https://ncbi.nlm.nih.gov/pubmed/26679095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18327
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