Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells

In both humans and animal models the development of Sjögren syndrome (SS) and non-SS keratoconjunctivitis sicca (KCS) increases with age. Here, we investigated the ocular surface and lacrimal gland phenotype of NOD.B10.H2(b) mice at 7–14, 45–50, and 96–100 weeks. Aged mice develop increased corneal...

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Udgivet i:Mucosal Immunol
Main Authors: Coursey, Terry G., Bian, Fang, Zaheer, Mahira, Pflugfelder, Stephen C., Volpe, Eugene A., de Paiva, Cintia S.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380589/
https://ncbi.nlm.nih.gov/pubmed/27706128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2016.83
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