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Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei

Trypanosoma brucei, causing African sleeping-sickness, exploits quorum-sensing (QS) to generate the ‘stumpy forms’ necessary for the parasite’s transmission to tsetse-flies. These quiescent cells are generated by differentiation in the bloodstream from proliferative slender forms. Using genome-wide...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Rico, Eva, Ivens, Alasdair, Glover, Lucy, Horn, David, Matthews, Keith R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380359/
https://ncbi.nlm.nih.gov/pubmed/28334017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006279
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