Clustered Distribution of Natural Product Leads of Drugs in the Chemical Space as Influenced by the Privileged Target-Sites

Some natural product leads of drugs (NPLDs) have been found to congregate in the chemical space. The extent, detailed patterns, and mechanisms of this congregation phenomenon have not been fully investigated and their usefulness for NPLD discovery needs to be more extensively tested. In this work, w...

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Vydáno v:Sci Rep
Hlavní autoři: Tao, Lin, Zhu, Feng, Qin, Chu, Zhang, Cheng, Chen, Shangying, Zhang, Peng, Zhang, Cunlong, Tan, Chunyan, Gao, Chunmei, Chen, Zhe, Jiang, Yuyang, Chen, Yu Zong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380136/
https://ncbi.nlm.nih.gov/pubmed/25790752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09325
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