Clustered Distribution of Natural Product Leads of Drugs in the Chemical Space as Influenced by the Privileged Target-Sites

Some natural product leads of drugs (NPLDs) have been found to congregate in the chemical space. The extent, detailed patterns, and mechanisms of this congregation phenomenon have not been fully investigated and their usefulness for NPLD discovery needs to be more extensively tested. In this work, w...

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Publicat a:Sci Rep
Autors principals: Tao, Lin, Zhu, Feng, Qin, Chu, Zhang, Cheng, Chen, Shangying, Zhang, Peng, Zhang, Cunlong, Tan, Chunyan, Gao, Chunmei, Chen, Zhe, Jiang, Yuyang, Chen, Yu Zong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380136/
https://ncbi.nlm.nih.gov/pubmed/25790752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09325
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