Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress

In the asexual blood stages of malarial infection, merozoites invade erythrocytes and replicate within a parasitophorous vacuole to form daughter cells that eventually exit (egress) by sequential rupture of the vacuole and erythrocyte membranes. The current model is that PKG, a malarial cGMP-depende...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hale, Victoria L., Watermeyer, Jean M., Hackett, Fiona, Vizcay-Barrena, Gema, van Ooij, Christiaan, Thomas, James A., Spink, Matthew C., Harkiolaki, Maria, Duke, Elizabeth, Fleck, Roland A., Blackman, Michael J., Saibil, Helen R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380091/
https://ncbi.nlm.nih.gov/pubmed/28292906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619441114
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