Proteolytic Activation of the Essential Parasitophorous Vacuole Cysteine Protease SERA6 Accompanies Malaria Parasite Egress from Its Host Erythrocyte

The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). The PV and host cell membranes eventually rupture, releasing merozoites in a process called egress. Certain inhibitors of serine and cysteine proteases block egress, indicating a crucial role for proteases. The...

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Detalhes bibliográficos
Main Authors: Ruecker, Andrea, Shea, Michael, Hackett, Fiona, Suarez, Catherine, Hirst, Elizabeth M. A., Milutinovic, Katarina, Withers-Martinez, Chrislaine, Blackman, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488066/
https://ncbi.nlm.nih.gov/pubmed/22984267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400820
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