Evolutionary insights into T-type Ca(2+) channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue

Four-domain voltage-gated Ca(2+) (Ca(v)) channels play fundamental roles in the nervous system, but little is known about when or how their unique properties and cellular roles evolved. Of the three types of metazoan Ca(v) channels, Ca(v)1 (L-type), Ca(v)2 (P/Q-, N- and R-type) and Ca(v)3 (T-type),...

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Bibliographic Details
Published in:J Gen Physiol
Main Authors: Smith, Carolyn L., Abdallah, Salsabil, Wong, Yuen Yan, Le, Phuong, Harracksingh, Alicia N., Artinian, Liana, Tamvacakis, Arianna N., Rehder, Vincent, Reese, Thomas S., Senatore, Adriano
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379919/
https://ncbi.nlm.nih.gov/pubmed/28330839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611683
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