Specific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer

BACKGROUND: Activating mutations in KRAS have been suggested as potential predictive and prognostic biomarkers. However, the prognostic impact of specific point mutations remains less clear. This study assessed the prognostic impact of specific KRAS mutations on survival for patients with colorectal...

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Podrobná bibliografie
Vydáno v:Br J Cancer
Hlavní autoři: Jones, Robert P, Sutton, Paul A, Evans, Jonathan P, Clifford, Rachel, McAvoy, Andrew, Lewis, James, Rousseau, Abigail, Mountford, Roger, McWhirter, Derek, Malik, Hassan Z
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379149/
https://ncbi.nlm.nih.gov/pubmed/28208157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.37
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