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Rare codons regulate KRas oncogenesis
Oncogenic mutations in the small Ras GTPases KRas, HRas, or NRas render the encoded proteins constitutively GTP-bound and active, which promote cancer [1]. Ras proteins share ~85% amino acid identity [2], are activated by [3] and signal through [4] the same proteins, and can exhibit functional redun...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3567844/ https://ncbi.nlm.nih.gov/pubmed/23246410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.11.031 |
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