Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy

Alzheimer disease (AD) represents a major medical problem where mono-therapeutic interventions demonstrated only a limited efficacy so far. We explored the possibility of developing a combinational therapy that might prevent the degradation of neuronal and endothelial structures in this disease. We...

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Udgivet i:Sci Rep
Main Authors: Chumakov, Ilya, Nabirotchkin, Serguei, Cholet, Nathalie, Milet, Aude, Boucard, Aurélie, Toulorge, Damien, Pereira, Yannick, Graudens, Esther, Traoré, Sory, Foucquier, Julie, Guedj, Mickael, Vial, Emmanuel, Callizot, Noëlle, Steinschneider, Rémy, Maurice, Tangui, Bertrand, Viviane, Scart-Grès, Catherine, Hajj, Rodolphe, Cohen, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378993/
https://ncbi.nlm.nih.gov/pubmed/25566747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07608
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