Over expression of hRad9 protein correlates with reduced chemosensitivity in breast cancer with administration of neoadjuvant chemotherapy

Human Rad 9 (hRad9), part of the Rad9-Hus1-Rad1 complex plays an important role in DNA damage repair as an up-stream regulator of checkpoint signaling, however little is known about its role in response to chemotherapy of breast cancer and whether hRad9 inhibition can potentiate the cytotoxic effect...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Yun, Haiqin, Shi, Ranran, Yang, Qingrui, Zhang, Xiaofang, Wang, Yan, Zhou, Xingchen, Mu, Kun
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378947/
https://ncbi.nlm.nih.gov/pubmed/25520248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07548
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