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Dysregulation of PLDN (Pallidin) is a mechanism for platelet dense granule deficiency in RUNX1 haplodeficiency

BACKGROUND: Inherited RUNX1 haplodeficiency is associated with thrombocytopenia and platelet dysfunction. Dense granule (DG) deficiency is reported in patients with RUNX1 haplodeficiency, but the molecular mechanisms are unknown. Platelet mRNA expression profiling in a patient previously reported by...

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Detalhes bibliográficos
Publicado no:J Thromb Haemost
Main Authors: Mao, G.F., Goldfinger, L.E., Fan, D.C., Lambert, M. P., Jalagadugula, G., Freishtat, R., Rao, A. K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378588/
https://ncbi.nlm.nih.gov/pubmed/28075530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13619
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