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Inositol Depletion Induced by Acute Treatment of the Bipolar Disorder Drug Valproate Increases Levels of Phytosphingosine

Bipolar disorder (BD) is a severe psychiatric illness affecting ∼1% of the world population. Valproate (VPA) and lithium, widely used for the treatment of BD, are not universally effective. These drugs have been shown to cause inositol depletion, but translating this observation to a specific therap...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Jadhav, Shyamalagauri, Russo, Sarah, Cowart, L. Ashley, Greenberg, Miriam L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377808/
https://ncbi.nlm.nih.gov/pubmed/28100786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775460
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