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Valproate Induces the Unfolded Protein Response by Increasing Ceramide Levels
Bipolar disorder (BD), which is characterized by depression and mania, affects 1–2% of the world population. Current treatments are effective in only 40–60% of cases and cause severe side effects. Valproate (VPA) is one of the most widely used drugs for the treatment of BD, but the therapeutic mecha...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5064004/ https://ncbi.nlm.nih.gov/pubmed/27590340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752634 |
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