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Valproate Induces the Unfolded Protein Response by Increasing Ceramide Levels

Bipolar disorder (BD), which is characterized by depression and mania, affects 1–2% of the world population. Current treatments are effective in only 40–60% of cases and cause severe side effects. Valproate (VPA) is one of the most widely used drugs for the treatment of BD, but the therapeutic mecha...

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Vydáno v:J Biol Chem
Hlavní autoři: Jadhav, Shyamalagauri, Russo, Sarah, Cottier, Stéphanie, Schneiter, Roger, Cowart, Ashley, Greenberg, Miriam L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064004/
https://ncbi.nlm.nih.gov/pubmed/27590340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752634
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