Heterochromatin Protein 1γ Is a Novel Epigenetic Repressor of Human Embryonic ϵ-Globin Gene Expression

Production of hemoglobin during development is tightly regulated. For example, expression from the human β-globin gene locus, comprising β-, δ-, ϵ-, and γ-globin genes, switches from ϵ-globin to γ-globin during embryonic development and then from γ-globin to β-globin after birth. Expression of human...

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Udgivet i:J Biol Chem
Main Authors: Wang, Yadong, Wang, Ying, Ma, Lingling, Nie, Min, Ju, Junyi, Liu, Ming, Deng, Yexuan, Yao, Bing, Gui, Tao, Li, Xinyu, Guo, Chan, Ma, Chi, Tan, Renxiang, Zhao, Quan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377797/
https://ncbi.nlm.nih.gov/pubmed/28154185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.768515
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