A prospective study to assess the association between genotype, phenotype and Prakriti in individuals on phenytoin monotherapy

BACKGROUND: Genetic polymorphisms in drug metabolizing enzymes (DMEs) impart distinct drug metabolizing capacity and a unique phenotype to an individual. Phenytoin has large inter-individual variability in metabolism due to polymorphisms in CYP2C9 and CYP2C19. As per Ayurveda, Prakriti imparts a uni...

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Bibliographic Details
Published in:J Ayurveda Integr Med
Main Authors: Thaker, Saket J., Gandhe, Prajakta P., Godbole, Charuta J., Bendkhale, Shital R., Mali, Nitin B., Thatte, Urmila M., Gogtay, Nithya J.
Format: Artigo
Language:Inglês
Published: Elsevier 2017
Subjects:
Original Research Article (Clinical)
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377478/
https://ncbi.nlm.nih.gov/pubmed/28302415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaim.2016.12.001
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