Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3–mediated therapeutics

T cell–mediated immunotherapy is an attractive strategy for treatment in various disease areas. In this therapeutic approach, the CD3 complex is one of the key molecules to modulate T cell functions; however, in many cases, we cannot evaluate the drug candidates in animal experiments because the the...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Ueda, Otoya, Wada, Naoko A., Kinoshita, Yasuko, Hino, Hiroshi, Kakefuda, Mami, Ito, Tsuneo, Fujii, Etsuko, Noguchi, Mizuho, Sato, Kiyoharu, Morita, Masahiro, Tateishi, Hiromi, Matsumoto, Kaoru, Goto, Chisato, Kawase, Yosuke, Kato, Atsuhiko, Hattori, Kunihiro, Nezu, Junichi, Ishiguro, Takahiro, Jishage, Kou-ichi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377452/
https://ncbi.nlm.nih.gov/pubmed/28368009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45839
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