Thermo‐kinetic analysis space expansion for cyclophilin‐ligand interactions – identification of a new nonpeptide inhibitor using Biacore™ T200

We have established a refined methodology for generating surface plasmon resonance sensor surfaces of recombinant his‐tagged human cyclophilin‐A. Our orientation‐specific stabilisation approach captures his‐tagged protein under ‘physiological conditions’ (150 mm NaCl, pH 7.5) and covalently stabilis...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:FEBS Open Bio
Egile Nagusiak: Wear, Martin A., Nowicki, Matthew W., Blackburn, Elizabeth A., McNae, Iain W., Walkinshaw, Malcolm D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2017
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377415/
https://ncbi.nlm.nih.gov/pubmed/28396838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12201
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