Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

We have used polyclonal anti-synthetic peptide serum to study the role of retinoblastoma gene (RB) inactivation in a variety of human tumor cell lines. Our analysis indicates that inactivation of the RB protein, p105-Rb, is universal in retinoblastoma cells, vindicating the predictions of the Knudso...

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Detalles Bibliográficos
Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Horowitz, J M, Park, S H, Bogenmann, E, Cheng, J C, Yandell, D W, Kaye, F J, Minna, J D, Dryja, T P, Weinberg, R A
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1990
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53773/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2181449/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.7.2775
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Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

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