Identification of Rare PB2-D701N Mutation from a Patient with Severe Influenza: Contribution of the PB2-D701N Mutation to the Pathogenicity of Human Influenza

Several amino acid changes have been previously implicated in adaptation of avian influenza viruses to human hosts, among them the D701N change in the PB2 polymerase subunit that also is the main determinant of avian virus pathogenesis in animal models. However, previous studies using recombinant vi...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Nieto, Amelia, Pozo, Francisco, Vidal-García, Matxalen, Omeñaca, Manuel, Casas, Inmaculada, Falcón, Ana
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376584/
https://ncbi.nlm.nih.gov/pubmed/28421062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.00575
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