D701N mutation in the PB2 protein contributes to the pathogenicity of H5N1 avian influenza viruses but not transmissibility in guinea pigs

H5N1 highly pathogenic avian influenza virus (HPAIV) of clade 2.3.2 has been circulating in waterfowl in Southern China since 2003. Our previous studies showed that certain H5N1 HPAIV isolates within clade 2.3.2 from Southern China had high pathogenicity in different birds. Guinea pigs have been suc...

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Bibliografiske detaljer
Udgivet i:Front Microbiol
Main Authors: Jiao, Peirong, Wei, Liangmeng, Song, Yafen, Cui, Jin, Song, Hui, Cao, Lan, Yuan, Runyu, Luo, Kaijian, Liao, Ming
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2014
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243574/
https://ncbi.nlm.nih.gov/pubmed/25505461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2014.00642
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