D701N mutation in the PB2 protein contributes to the pathogenicity of H5N1 avian influenza viruses but not transmissibility in guinea pigs

H5N1 highly pathogenic avian influenza virus (HPAIV) of clade 2.3.2 has been circulating in waterfowl in Southern China since 2003. Our previous studies showed that certain H5N1 HPAIV isolates within clade 2.3.2 from Southern China had high pathogenicity in different birds. Guinea pigs have been suc...

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Dades bibliogràfiques
Publicat a:Front Microbiol
Autors principals: Jiao, Peirong, Wei, Liangmeng, Song, Yafen, Cui, Jin, Song, Hui, Cao, Lan, Yuan, Runyu, Luo, Kaijian, Liao, Ming
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243574/
https://ncbi.nlm.nih.gov/pubmed/25505461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2014.00642
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