D701N mutation in the PB2 protein contributes to the pathogenicity of H5N1 avian influenza viruses but not transmissibility in guinea pigs

H5N1 highly pathogenic avian influenza virus (HPAIV) of clade 2.3.2 has been circulating in waterfowl in Southern China since 2003. Our previous studies showed that certain H5N1 HPAIV isolates within clade 2.3.2 from Southern China had high pathogenicity in different birds. Guinea pigs have been suc...

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發表在:Front Microbiol
Main Authors: Jiao, Peirong, Wei, Liangmeng, Song, Yafen, Cui, Jin, Song, Hui, Cao, Lan, Yuan, Runyu, Luo, Kaijian, Liao, Ming
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2014
主題:
Microbiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243574/
https://ncbi.nlm.nih.gov/pubmed/25505461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2014.00642
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