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Tubulin acetylation protects long-lived microtubules against mechanical aging

Long-lived microtubules endow the eukaryotic cell with long-range transport abilities. While long-lived microtubules are acetylated on lysine 40 of α-tubulin (αK40), acetylation takes place after stabilization(1) and does not protect against depolymerization(2). Instead, αK40 acetylation has been pr...

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Veröffentlicht in:Nat Cell Biol
Hauptverfasser: Portran, Didier, Schaedel, Laura, Xu, Zhenjie, Théry, Manuel, Nachury, Maxence V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376231/
https://ncbi.nlm.nih.gov/pubmed/28250419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3481
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