Monoamine oxidase B inhibitor, selegiline, reduces (18)F-THK5351 uptake in the human brain

BACKGROUND: (18)F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of (18)F-THK5351 retention in brain regions thought to contain negligible concentrations of PHF raise questions about the interpretation of the positron emiss...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Ng, Kok Pin, Pascoal, Tharick A., Mathotaarachchi, Sulantha, Therriault, Joseph, Kang, Min Su, Shin, Monica, Guiot, Marie-Christine, Guo, Qi, Harada, Ryuichi, Comley, Robert A., Massarweh, Gassan, Soucy, Jean-Paul, Okamura, Nobuyuki, Gauthier, Serge, Rosa-Neto, Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374697/
https://ncbi.nlm.nih.gov/pubmed/28359327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-017-0253-y
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