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MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation
Retinoblastomas can arise from cone photoreceptor precursors in response to the loss of pRB function. Cone precursor-specific circuitry cooperates with pRB loss to initiate this process and subsequently contributes to the malignancy. Intrinsic high level MDM2 expression is a key component of the con...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5374018/ https://ncbi.nlm.nih.gov/pubmed/27748758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.350 |
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