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Parkin-mediated mitophagy is downregulated in browning of white adipose tissue

OBJECTIVE: Browning of white adipose tissue (WAT) promotes increased energy expenditure through the action of uncoupling protein 1 (UCP1), and is an attractive target to promote weight loss in obesity. Lowering of mitochondrial membrane potential by UCP1 is uniquely beneficial in this context; in ot...

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Détails bibliographiques
Publié dans:Obesity (Silver Spring)
Auteurs principaux: Taylor, David, Gottlieb, Roberta A.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373982/
https://ncbi.nlm.nih.gov/pubmed/28240819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.21786
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