FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging

A hallmark of aged mesenchymal stem/progenitor cells (MSCs) in bone marrow is the pivot of differentiation potency from osteoblast to adipocyte coupled with a decrease in self-renewal capacity. However, how these cellular events are orchestrated in the aging progress is not fully understood. In this...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Li, Hanjun, Liu, Pei, Xu, Shuqin, Li, Yinghua, Dekker, Joseph D., Li, Baojie, Fan, Ying, Zhang, Zhenlin, Hong, Yang, Yang, Gong, Tang, Tingting, Ren, Yongxin, Tucker, Haley O., Yao, Zhengju, Guo, Xizhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373872/
https://ncbi.nlm.nih.gov/pubmed/28240601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89511
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