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Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance
The nuclear receptors PPARα (encoded by NR1C1) and farnesoid X receptor (FXR, encoded by NR1H4) are activated in the liver in the fasted and fed state, respectively. PPARα activation induces fatty acid oxidation, while FXR controls bile acid homeostasis, but both nuclear receptors also regulate nume...
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| 出版年: | J Clin Invest |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5373864/ https://ncbi.nlm.nih.gov/pubmed/28287408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88893 |
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