Polygenic risk scores in familial Alzheimer disease

OBJECTIVE: To investigate the association between a genetic risk score (GRS) and familial late-onset Alzheimer disease (LOAD) and its predictive value in families multiply affected by the disease. METHODS: Using data from the National Institute on Aging Genetics Initiative for Late-Onset Alzheimer D...

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Publicado en:Neurology
Main Authors: Tosto, Giuseppe, Bird, Thomas D., Tsuang, Debby, Bennett, David A., Boeve, Bradley F., Cruchaga, Carlos, Faber, Kelley, Foroud, Tatiana M., Farlow, Martin, Goate, Alison M., Bertlesen, Sarah, Graff-Radford, Neill R., Medrano, Martin, Lantigua, Rafael, Manly, Jennifer, Ottman, Ruth, Rosenberg, Roger, Schaid, Daniel J., Schupf, Nicole, Stern, Yaakov, Sweet, Robert A., Mayeux, Richard
Formato: Artigo
Idioma:Inglês
Publicado: Lippincott Williams & Wilkins 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373783/
https://ncbi.nlm.nih.gov/pubmed/28213371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000003734
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