Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction

Pregnancy is a state of high metabolic demand. Fasting diverts metabolism to fatty acid oxidation, and the fasted response occurs much more rapidly in pregnant women than in the non-pregnant state. The product of the imprinted Delta-like homologue 1 gene (DLK1) is an endocrine signaling molecule tha...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Cleaton, Mary AM, Dent, Claire L, Howard, Mark, Corish, Jennifer A, Gutteridge, Isabelle, Sovio, Ulla, Gaccioli, Francesca, Takahashi, Nozomi, Bauer, Steven R, Charnock-Jones, D Steven, Powell, Theresa L, Smith, Gordon CS, Ferguson–Smith, Anne C, Charalambous, Marika
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373434/
https://ncbi.nlm.nih.gov/pubmed/27776119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3699
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