Dealing with an Unconventional Genetic Code in Mitochondria: The Biogenesis and Pathogenic Defects of the 5-Formylcytosine Modification in Mitochondrial tRNA(Met)

Human mitochondria contain their own genome, which uses an unconventional genetic code. In addition to the standard AUG methionine codon, the single mitochondrial tRNA Methionine (mt-tRNA(Met)) also recognises AUA during translation initiation and elongation. Post-transcriptional modifications of tR...

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Detalles Bibliográficos
Publicado en:Biomolecules
Autores principales: Van Haute, Lindsey, Powell, Christopher A., Minczuk, Michal
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5372736/
https://ncbi.nlm.nih.gov/pubmed/28257121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom7010024
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