NANOG Expression as a Responsive Biomarker during Treatment with Hedgehog Signal Inhibitor in Acute Myeloid Leukemia

Aberrant activation of the Hedgehog (Hh) signaling pathway is involved in the maintenance of leukemic stem cell (LSCs) populations. PF-0444913 (PF-913) is a novel inhibitor that selectively targets Smoothened (SMO), which regulates the Hh pathway. Treatment with PF-913 has shown promising results in...

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Udgivet i:Int J Mol Sci
Main Authors: Kakiuchi, Seiji, Minami, Yosuke, Miyata, Yoshiharu, Mizutani, Yu, Goto, Hideaki, Kawamoto, Shinichiro, Yakushijin, Kimikazu, Kurata, Keiji, Matsuoka, Hiroshi, Minami, Hironobu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5372502/
https://ncbi.nlm.nih.gov/pubmed/28245563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18030486
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