DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis

BACKGROUND: Multiple factors, including interactions between genetic and environmental risks, are important in susceptibility to rheumatoid arthritis (RA). However, the underlying mechanism is not fully understood. This study was undertaken to evaluate whether DNA methylation can mediate the interac...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Meng, Weida, Zhu, Zaihua, Jiang, Xia, Too, Chun Lai, Uebe, Steffen, Jagodic, Maja, Kockum, Ingrid, Murad, Shahnaz, Ferrucci, Luigi, Alfredsson, Lars, Zou, Hejian, Klareskog, Lars, Feinberg, Andrew P., Ekström, Tomas J., Padyukov, Leonid, Liu, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5372280/
https://ncbi.nlm.nih.gov/pubmed/28356135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1276-2
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