SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation

The serum- and glucocorticoid-regulated kinase (SGK1) controls cell transformation and tumor progression. SGK1 affects mitotic stability by regulating the expression of RANBP1/RAN. Here, we demonstrate that SGK1 fluctuations indirectly modify the maturation of pre-miRNAs, by modulating the equilibri...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Dattilo, Vincenzo, D’Antona, Lucia, Talarico, Cristina, Capula, Mjriam, Catalogna, Giada, Iuliano, Rodolfo, Schenone, Silvia, Roperto, Sante, Bianco, Cataldo, Perrotti, Nicola, Amato, Rosario
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371792/
https://ncbi.nlm.nih.gov/pubmed/28358001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45361
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