T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1

The nuclear pore complex (NPC) is the sole and selective gateway for nuclear transport, and its dysfunction has been associated with many diseases. The metazoan NPC subcomplex RanBP2, which consists of RanBP2 (Nup358), RanGAP1-SUMO1, and Ubc9, regulates the assembly and function of the NPC. The role...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: He, Yujiao, Yang, Zhiguo, Zhao, Chen-si, Xiao, Zhihui, Gong, Yu, Li, Yun-Yi, Chen, Yiqi, Du, Yunting, Feng, Dianying, Altman, Amnon, Li, Yingqiu
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2021
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225385/
https://ncbi.nlm.nih.gov/pubmed/34110283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67123
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